Hydrochloric Acid → HCID 14210571, compound

Participants

Reaction Steps

A solution of (Z)-4-amino-3,5-dichloro-α-[[(phenylmethyl)[6-[[3-(2-pyridinyl)-2-propenyl]oxy]hexyl]amino]methyl]benzenemethanol (0.65 g) in ethanol (15 ml) containing hydrochloric acid (2.7 mmol) was hydrogenated over 10% palladium on charcoal (0.15 g), filtered and evaporated. The residue was partitioned between aqueous sodium bicarbonate (1M; 30 ml) and ethyl acetate (150 ml) and the dried organic phase was evaporated to give a brown gum. The gum was purified by FCC eluting with System A (93:7:1→85:15:1), to give the title compound as a white solid (0.32 g) m.p. 38°-41°.

Provenance & Evidence