Benzoyl chloride → HCID 23045025, compound

Participants

Reaction Steps

To a mixture of 1-(3,4,5-trimethoxybenzyl)piperazine (0.5 g), potassium carbonate (3 g), ethyl acetate (30 ml) and water (20 ml) is added dropwise benzoyl chloride (1 ml) at room temperature with stirring. The mixture is stirred for one hour. Ethyl acetate (100 ml) and water (100 ml) are added to the mixture, followed by extraction. The ethyl acetate layer is separated, washed with water, dried, and concentrated under reduced pressure. The residue is dissolved in ethyl ether (200 ml). To the mixture is added hydrogen chloride - ethyl acetate (1N) (4 ml). Resultant precipitates are recrystallized from ethanol - ethyl ether to afford 1-benzoyl-4-(3,4,5-trimethoxybenzyl)piperazine hydrochloride (0.5 g) as colorless powdery crystals, m.p. 220°-225° C. (decomp.).

Provenance & Evidence