反应详情

A mixture of 2-[(3-pyridinyl)oxy]ethanol (1.9 g), 1,6-dibromohexane (6 ml), tetra-n-butylammonium bisulphate (0.5 g) and 50% w/v sodium hydroxide (20 ml) was stirred vigorously for 5 h, diluted with water (30 ml) and extracted with ethyl acetate (3×50 ml). The combined organic extracts were dried and evaporated in vacuo to give an oil which was purified by FCC eluting with hexane→ethylacetate to give the title compound (2.3 g) as an oil. T.l.c. (System E 80:20:1) Rf 0.63

1. extractionextracted with ethyl acetate (3×50 ml)
2. customThe combined organic extracts were dried
3. customevaporated in vacuo
4. customto give an oil which
5. customwas purified by FCC
6. washeluting with hexane→ethylacetate