反应详情

A solution of 2-[2-[2-[(6-bromohexyl)oxy]ethoxy]ethyl]pyridine (1.55 g) in benzylamine (3.1 g) was heated at 125° under nitrogen for 3 h. The solution was allowed to cool and then partitioned between 8% sodium bicarbonate (100 ml) and diethyl ether (2×100 ml). The solvent was evaporated in vacuo and the residual oil distilled (Kugelrohr) to remove excess benzylamine. Purification by FCC eluting with System G 92:8:1) gave the title compound (1.38 g) as a colourless oil. T.l.c. (System G 95:5:1) Rf 0.14

1. temperatureto cool
2. custompartitioned between 8% sodium bicarbonate (100 ml) and diethyl ether (2×100 ml)
3. customThe solvent was evaporated in vacuo
4. distillationthe residual oil distilled (Kugelrohr)
5. customto remove excess benzylamine
6. customPurification by FCC
7. washeluting with System G 92:8:1)