反应详情

A 2 liter autoclave was charged with 148 g of N1 -methyl-N4 -(2,4-dinitrobenzoyl)piperazine, 1300 ml of methanol and 5 g of a 5% palladium on carbon/50% water catalyst. The mixture was hydrogenated under 800 psi hydrogen pressure while maintaining the temperature below 100° C. with cooling. Hydrogen uptake ceased after 30 min. The mixture was cooled, filtered and the methanol removed under reduced pressure to give 101 g of N1 -methyl-N4 -(2,4-diaminobenzoyl)- piperazine, a light tan solid, mp 192° C.

1. temperaturewhile maintaining the temperature below 100° C.
2. temperaturewith cooling
3. temperatureThe mixture was cooled
4. filtrationfiltered
5. customthe methanol removed under reduced pressure