Acetic Anhydride → HCID 19023492, compound

HRID 2108164Notes

Reaction equation

HRID 2108164 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[N:7]1[CH2:12][CH2:11][N:10]([CH2:13][CH2:14][CH2:15][CH2:16][N:17]2[C:21](=[O:22])[C:20]3[CH:23]=[CH:24][C:25]([NH2:27])=[CH:26][C:19]=3[S:18]2(=[O:29])=[O:28])[CH2:9][CH2:8]1.[C:30](OC(=O)C)(=[O:32])[CH3:31]>>[N:3]1[CH:4]=[CH:5][CH:6]=[N:1][C:2]=1[N:7]1[CH2:12][CH2:11][N:10]([CH2:13][CH2:14][CH2:15][CH2:16][N:17]2[C:21](=[O:22])[C:20]3[CH:23]=[CH:24][C:25]([NH:27][C:30](=[O:32])[CH3:31])=[CH:26][C:19]=3[S:18]2(=[O:28])=[O:29])[CH2:9][CH2:8]1

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 19023477HCID 19023477, compound

Product 1

HCID 19023492HCID 19023492, compound

Procedure

200 ml of acetic anhydride are added to 0.06 mol of 2-(4-(4-(2-pyrimidinyl)-1-piperazinyl)butyl)-6-amino-1,2-benzoisothiazol-3(2H)one 1,1-dioxide, and the mixture is stirred at room temperature for 12 hours. It is then evaporated to dryness, isopropyl ether is added and the mixture is stirred for 1 hour. It is then filtered and the colourless crystals are dried in vacuo.

Workup

  1. customIt is then evaporated to dryness, isopropyl ether
  2. additionis added
  3. stirringthe mixture is stirred for 1 hour
  4. filtrationIt is then filtered
  5. customthe colourless crystals are dried in vacuo

Sources & evidence

ORD record
ord-578faa57e0d04bf8ba7230d8878b355d
Source dataset
uspto-grants-1990_06
Patent number
US04937343

Reaction notes

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