反应详情

A mixture of 4-bromo-3-methylaniline (3.72 g, 20 mmol) and 5-formamido-1,2,4-triazole-3-sulfonyl chloride (2.10 g, 10 mmol) in 50 mL of acetonitrile was refluxed under nitrogen until all of the sulfonyl chloride has been consumed (approximately 1 hr). The mixture was cooled and filtered. The precipitate was dispersed in 200 mL of 1% aqueous HCl solution and filtered again to yield the title compound as a white solid, 3.0 g (84%) m.p. 282°-284° C., M+ -Br at 280.

1. customhas been consumed (approximately 1 hr)
2. temperatureThe mixture was cooled
3. filtrationfiltered
4. additionThe precipitate was dispersed in 200 mL of 1% aqueous HCl solution
5. filtrationfiltered again