HCID 178418361, compound → HCID 178425411, compound

Participants

Reaction Steps

A 3-necked flask equipped with a thermometer, reflux condenser with a nitrogen outlet, a sparge tube to introduce hydrogen and a spinbar was charged with the product of Example 11 (2 g, 4.66 mmol) and 100 mL of 95% ethanol. The mixture was stirred rapidly and purged with nitrogen and 150 mg of 10% Pd/C was added. Hydrogen gas was bubbled through the mixture while heating to reflux. After three hr of reflux the reaction was essentially complete. The mixture was purged with nitrogen and filtered. The filtrate was concentrated to yield the title compound as an off white solid, 1.5 g (98%) m.p. 198°-200° C.

Provenance & Evidence