Benzylamine → 3-(benzylamino)butanoic acid

HRID 2108185Notes

Reaction equation

HRID 2108185 reaction equation
COC1[O:8][C:7](=[O:9])[CH2:6][CH:5]([CH3:10])O1.[CH2:11]([NH2:18])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>ClCCl>[CH2:11]([NH:18][CH:5]([CH3:10])[CH2:6][C:7]([OH:8])=[O:9])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

Participants

4

Reactant 2

HCID 7504BenzylamineHCID 23045689HCID 23045689, compound

Product 1

HCID 27336823-(benzylamino)butanoic acid

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The product of Example 2, 2-methoxy-6-methyl-1,3-dioxan-4-one, was reacted with benzylamine in dichloromethane at room temperature for 24 hours. This afforded optically active 3-(N-benzylamino) butyric acid.

Sources & evidence

ORD record
ord-7c1411bff14244ef8a4d55fb93afa3c9
Source dataset
uspto-grants-1990_06
Patent number
US04937359

Reaction notes

Loading…