Methanol → Methyl 3-(3-pyridinyl)benzoate

Participants

Reaction Steps

A mixture of methyl-3-(1-propionylpiperidin-3-yl)benzoate (4.8 g, 0.17 mol), sodium hydroxide pellets (5 g), methanol (80 ml) and water (20 ml) was stirred until TLC indicated that no starting material remained (4 hours). The methanol was evaporated and the alkaline water layer was washed with ether, acidified with hydrochloride acid and extracted with chloroform. Evaporation gave the product (4.0 g, 69% yield from methyl-3-(3-pyridyl)-benzoate) as an oil which crystallized after several weeks on standing. (Mp. 125°-126° C.)

Provenance & Evidence