Ethyl Acetate → p-Toluenesulfonic acid

Participants

Reaction Steps

A compound of Formula (IV) wherein the protecting group R5 is a trityl group is dissolved in a reaction-inert solvent (e.g., ethyl acetate), 1.0 to 1.5 molar equivalents of p-toluenesulfonic acid monohydrate is added under ice-cooling, and then the mixture is stirred for 1 to 5 hours to give the compound of Formula (V) in the form of p-toluenesulfonic acid salt. If necessary, the p-toluenesulfonic acid salt is treated with a base to give the compound of Formula (V) in the form of the free base.

Provenance & Evidence