Diethyl Ether → HCID 88605859, compound

Participants

Reaction Steps

To a mixture of 3.5 ml of trifluoroacetic acid and 0.7 ml of anisole was added under ice-cooling 250 mg (0.25 mM) of 4-methoxybenzyl 7β-{2-(2-tritylaminothiazol-4yl)-2-[(Z)-2,4-dimethoxybenzyloxyimino]acetamido}-3-[(Z)-2-methoxycarbonylvinylthio]-3-cephem-4-carboxylate, and the mixture was stirred for 40 minutes and then at room temperature for 10 minutes. After the reaction, the reaction solution was slowly added dropwise to a mixture of diethyl ether and n-hexane (1:2, 30 ml), and the formed crystals were collected by filtration to give 150 mg of 7β-{2-(2-aminothiazol-4-yl)-2-[(Z)-hydroxyimino]acetamido}-3-[(Z)-2-methoxycarbonylvinylthio]-3-cephem-4-carboxylic acid trifluoroacetate.

Provenance & Evidence