Hexamethyldisilazane → HCID 178454809, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of di-ter.butylphosphite (2.13 g; 0.11 mol) and hexamethyldisilazane (8.87 g; 0.055 mol) was kept under nitrogen at 100° C. for 2 hours. The mixture was slowly cooled at 15° C. 2(S)-acetoxypropionyl chloride (15.0 g; 0.1 mol) was added under nitrogen at 15° C. in 15 minutes, thereafter the low-boiling compounds were removed by distillation under vacuum (20°-30° C./10 mmHg). Di-ter.butyl 2(S)-acetoxypropionyl phosphonate (27.72 g) was thereby obtained as oil.

Provenance & Evidence