HuagongsheHuagongshe Chemistry Print Report · For research reference only
4,5-Difluorophthalic Anhydride → 3,4-Difluorobenzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4,5-Difluorophthalic Anhydride | HCID 639745 | — |
| Reactant | 4,5-Difluorophthalic Acid | HCID 643382 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Solvent | Dimethylacetamide | HCID 31374 | — |
| Product | 3,4-Difluorobenzoic acid | HCID 99166 | — |
Reaction Steps
We have found that 4,5-difluorophthalic anhydride and 4,5-difluorophthalic acid may be decarboxylated in high yield to 3,4-difluorobenzoic acid in N-methyl-2-pyrrolidone or dimethyl acetamide using copper, copper oxide, copper salts, or halides and salts of Zn, Cd, Ag and Ni as a catalyst.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04937377 |
| Source dataset | uspto-grants-1990_06 |
| ORD ID | ord-5ca0015295c342208e748099287e6083 |
| Source note | uspto-grants-1990_06 |