Sodium Iodide → HCID 131716450, compound

Participants

Reaction Steps

A mixture of 7.60 g (0.021 mole) of 6-bromo-(6,7-dimethoxy-2-naphthalenyl)-1-hexanone, 5.96 g (0.021 mole) of 2,4-dihydroxy-3-propylbenzoic acid phenylmethyl ester, 5.75 g (0.042 mole) of potassium carbonate and 3.20 g (0.021 mole) of sodium iodide in 100 mL of acetone and 25 mL of dimethylformamide was stirred at reflux for 26 hours. The solvents were removed under reduced pressure and the crude product was purified by HPLC using 2% ethyl acetate-toluene, to give 8.14 g (69% yield) of 2-hydroxy-4-[[6,7-dimethoxy-2-naphthalenyl)-6-oxohexyl]oxy]-3-propylbenzoic acid phenylmethyl ester.

Provenance & Evidence