Hydrochloric Acid → HCID 14498218, compound

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Reaction Steps

6.8 g (18.4 mol) of the compound from Example 3 are heated to reflux for 18 hours in 30 ml of ethanol and 3.4 ml of 6N sodium hydroxide solution. The mixture is then acidified using 1N hydrochloric acid and the deposited precipitate is filtered off with suction. The precipitate is dissolved again in ethyl acetate, extracted using 1N hydrochloric acid and saturated sodium chloride solution, dried over sodium sulphate and concentrated to dryness. Recrystallization from ether/petroleum ether yields 4.35 g (69% of theory) of colorless crystals of melting point 212° C.

Provenance & Evidence