HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl Bromide → 1-(6-Bromohexyl)-2,3-bis(phenylmethoxy)benzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl Bromide | HCID 7498 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Ethanamine, 2-(2-methoxyethoxy)-N,N-bis[2-(2-methoxyethoxy)ethyl]- | HCID 112414 | — |
| Reactant | 1-(6-Bromohexyl)-2,3-dihydroxybenzene | HCID 14986284 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 1-(6-Bromohexyl)-2,3-bis(phenylmethoxy)benzene | HCID 14986434 | 561.1% |
Reaction Steps
A mixture of 31.3 g (0.115 mol) of 1-(6-bromohexyl)-2,3-dihydroxybenzene, 41 mL (0.34 mol) of benzyl bromide, 47.5 g (0.34 mol) of potassium carbonate and 4.4 mL (13.6 mmol) of tris[2-(2-methoxyethoxy)ethyl]amine (TDA-1) in 750 mL of toluene was stirred at reflux for 40 hours. The reaction mixture was washed with half-saturated brine, dried and concentrated under reduced pressure to which was purified by HPLC using 25% toluene-hexane to give 34.6 g (67% yield) of 1-(6-bromohexyl)-2,3-bis(phenylmethoxy)benzene as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04937373 |
| Source dataset | uspto-grants-1990_06 |
| ORD ID | ord-b57bd7ddc66041cb975fc8b9473ee627 |
| Source note | uspto-grants-1990_06 |