HCID 15086661, compound → HCID 15086664, compound

Participants

Reaction Steps

A mixture of 4.9 g (8.3 mmol) of (S)-alpha-methyl-6-[6-[2,3-bis(phenylmethoxy)phenyl]hexyloxy]-2-naphthaleneacetic acid and 0.5 g of 10% palladium on carbon in 100 mL of ethyl acetate was shaken in a hydrogen atmosphere for 22 hours. The reaction mixture was filtered through Celite and the filtrate was concentrated at reduced pressure to an oil which was crystallized from ether-hexane to give 2.9 g (85% yield), mp 136°-139°, of (S)-[6-(2,3-dihydroxyphenyl)hexyloxy]-alpha-methyl-2-naphthaleneacetic acid.

Provenance & Evidence