Isobutylene → HCID 86744052, compound

HRID 2108277Notes

Reaction equation

HRID 2108277 reaction equation
[CH3:1][NH:2][C:3]([CH2:5][CH:6]=[C:7]([CH2:11][CH:12]([CH3:14])[CH3:13])[C:8]([OH:10])=[O:9])=[O:4].[CH3:15][C:16](=[CH2:18])[CH3:17]>C(Cl)(Cl)Cl.S(=O)(=O)(O)O>[CH3:1][NH:2][C:3]([CH2:5][CH:6]=[C:7]([CH2:11][CH:12]([CH3:14])[CH3:13])[C:8]([O:10][C:16]([CH3:18])([CH3:17])[CH3:15])=[O:9])=[O:4]

Participants

5

Reactant 2

HCID 8255IsobutyleneHCID 53664648HCID 53664648, compound

Product 1

HCID 86744052HCID 86744052, compound

Reagents, catalysts & solvents 2

HCID 1118Sulfuric AcidCatalystHCID 6212ChloroformSolvent

Procedure

A suspension of 4-methylaminocarbonyl-2-(2-methylpropyl)but-2-enoic acid (2.4 g) in chloroform (35 ml) was treated with an excess of isobutylene (30 ml) and concentrated sulphuric acid (3 drops) was added as catalyst. The mixture was stirred at room temperature in a sealed vessel for 8 days. The product was purified by silica gel chromatography [chloroform(2.5 g, 81%), m.p. 35°-36° C. (pentane).

Workup

  1. additionwas added as catalyst
  2. customThe product was purified by silica gel chromatography [chloroform(2.5 g, 81%), m.p. 35°-36° C. (pentane)

Sources & evidence

ORD record
ord-e439b27f5aa148a7b9561ff532946c3a
Source dataset
uspto-grants-1990_06
Patent number
US04937243

Reaction notes

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