HCID 86611510, compound → HCID 68874444, compound

HRID 2108320Notes

Reaction equation

HRID 2108320 reaction equation
[CH2:1]([N:8]1[CH2:18][C:17]([F:20])([F:19])[C:11]2(SCCCS2)[C:10]([F:22])([F:21])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>[Ni]>[CH2:1]([N:8]1[CH2:9][C:10]([F:21])([F:22])[CH2:11][C:17]([F:20])([F:19])[CH2:18]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 1

HCID 86611510HCID 86611510, compound

Product 1

HCID 68874444HCID 68874444, compound

Reagents, catalysts & solvents 1

HCID 935NickelCatalyst

Procedure

React 4.0 mmol of the product of Example 29 with Raney nickel according to the general procedure set forth in Example 23 and purify by silica gel chromatography using methylene chloride/methanol/saturated NH4OH as eluant to yield the title compound.

Workup

  1. custompurify by silica gel chromatography

Sources & evidence

ORD record
ord-efe6782bce194c30acc2889330b135d9
Source dataset
uspto-grants-2009_04
Patent number
US07514068B2

Reaction notes

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