HCID 86609570, compound → HCID 68853337, compound

Participants

Reaction Steps

10 mg of the ethyl (2E)-3-(1-{9-[(3S,5S,2R,4R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-(cyclopentylamino)purin-2-yl}pyrazol-4-yl)prop-2-enoate prepared in the preceding step was combined in a par bottle with 3 mL of MeOH and approximately 5 mg of 10% Pd/C (Aldrich) and the solution hydrogenated at 25-30 psi at room temperature. The Pd/c was filtered off and the filtrate condensed to provide ethyl 3-(1-{9-[(3S,5S,2R,4R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-(cyclopentylamino)purin-2-yl}pyrazol-4-yl)propanoate.

Provenance & Evidence