p-Toluenesulfonic acid → HCID 14804719, compound

Participants

Reaction Steps

A solution of L-phenyl lactic acid methyl ester (20.0 g, 111 mmol) in CH2Cl2 (300 mL) was treated with dihydropyran (9.32 g, 111 mmol) and p-toluenesulphonic acid (56 mg) and stirred at room temperature for 20 minutes. The reaction is quenched with 1 N NaOH and then washed with water, brine and dried over Na2SO4. The solution is filtered and the solvent removed under vacuum to give 28 grams of the THP protected alcohol as an oil. This was used without further purification.

Provenance & Evidence