2-Phenylethanol → HCID 11154365, compound

HRID 2108372Notes

Reaction equation

HRID 2108372 reaction equation
[CH:1]1([CH2:4][CH2:5][OH:6])[CH2:3][CH2:2]1.C1(CCO)C=CC=CC=1.Cl[C:17]1[N:22]=[N:21][C:20]([N:23]2[CH2:28][CH2:27][N:26]([C:29]([C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][C:32]=3[C:37]([F:40])([F:39])[F:38])=[O:30])[CH2:25][CH2:24]2)=[CH:19][CH:18]=1>>[CH:1]1([CH2:4][CH2:5][O:6][C:17]2[N:22]=[N:21][C:20]([N:23]3[CH2:24][CH2:25][N:26]([C:29]([C:31]4[CH:36]=[CH:35][CH:34]=[CH:33][C:32]=4[C:37]([F:38])([F:40])[F:39])=[O:30])[CH2:27][CH2:28]3)=[CH:19][CH:18]=2)[CH2:3][CH2:2]1

Participants

4

Reactant 3

HCID 60542-PhenylethanolHCID 1376422-Cyclopropylethan-1-olHCID 86024941HCID 86024941, compound

Product 1

HCID 11154365HCID 11154365, compound

Procedure

Following the procedure set forth above in Example 5, only making variations using 2-cyclopropylethanol to replace 2-phenylethanol to react with [4-(6-chloropyridazin-3-yl)piperazin-1-yl]-(2-trifluoromethylphenyl)methanone, the title compound was obtained as a white solid (56 mg, 74.8% yield). 1H NMR (400 MHz, CDCl3) δ 7.72, 7.60-7.63, 7.52-7.56, 7.35, 7.03, 6.87, 4.46, 3.91-3.98, 3.55, 3.46-3.50, 3.31, 1.68, 0.79-0.84, 0.43-0.46, 0.11-−0.79.

Sources & evidence

ORD record
ord-79d9b8fa8e294511807c1c2783fb8beb
Source dataset
uspto-grants-2009_04
Patent number
US07514436B2

Reaction notes

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