Isoamyl mercaptan → HCID 11293539, compound

HRID 2108374Notes

Reaction equation

HRID 2108374 reaction equation
[CH3:1][CH:2]([CH3:6])[CH2:3][CH2:4][SH:5].C1(CCS)C=CC=CC=1.Cl[C:17]1[N:22]=[N:21][C:20]([N:23]2[CH2:28][CH2:27][N:26]([C:29]([C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][C:32]=3[C:37]([F:40])([F:39])[F:38])=[O:30])[CH2:25][CH2:24]2)=[CH:19][CH:18]=1>>[CH3:1][CH:2]([CH3:6])[CH2:3][CH2:4][S:5][C:17]1[N:22]=[N:21][C:20]([N:23]2[CH2:24][CH2:25][N:26]([C:29]([C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][C:32]=3[C:37]([F:38])([F:40])[F:39])=[O:30])[CH2:27][CH2:28]2)=[CH:19][CH:18]=1

Participants

4

Reactant 3

HCID 10925Isoamyl mercaptanHCID 781262-PhenylethanethiolHCID 86024941HCID 86024941, compound

Product 1

HCID 11293539HCID 11293539, compound

Procedure

Following the procedure set forth above in Example 6, only making variations using 3-methylbutane-1-thiol to replace 2-phenylethanethiol to react with [4-(6-chloropyridazin-3-yl)piperazin-1-yl]-(2-trifluoromethylphenyl)methanone, the title compound was obtained as a white solid (24.3 mg, 26.4% yield). 1H NMR (400 MHz, CDCl3) δ 8.04, 7.98, 6.99, 3.79, 3.56, 3.45-3.47, 3.40, 1.85-1.87, 1.52, 0.72-0.80, 0.46-0.48, 0.09-0.10.

Sources & evidence

ORD record
ord-460c49acce1b4d029a5e9651a125ed04
Source dataset
uspto-grants-2009_04
Patent number
US07514436B2

Reaction notes

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