HCID 67213868, compound → HCID 67213469, compound

Participants

Reaction Steps

A stirred solution of 2-nitro-3-(4-pyridinyl)-1H-imidazole (1.19 g, 6.26 mmol) in 7N methanol/NH3 (25 ml) and methanol (25 ml) was hydrogenated at room temperature on Raney Nickel (1 g) for 4 h. The catalyst was removed by filtration and the solution evaporated. The crude product was purified by column chromatography on silica gel (dichloromethane/methanol/NH4OH 40:10:1) to yield 2-amino-3-(4-pyridinyl)-1H-imidazole (0.85 g, 85%) as a green solid. MS (ISP) 161.2 [(M+H)+]; mp 190° C.

Provenance & Evidence