1-(3-Chlorophenyl)ethanone → HCID 67213123, compound

HRID 2108388Notes

Reaction equation

HRID 2108388 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:8](=O)[CH2:9][C:10](=O)[C:11]([F:14])([F:13])[F:12])[CH:5]=[CH:6][CH:7]=1.CC(C1C=CC=C(Cl)C=1)=O.[NH2:27][C:28]1[C:32]([C:33]#[N:34])=[CH:31][NH:30][N:29]=1>>[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:9]=[C:10]([C:11]([F:14])([F:13])[F:12])[N:29]3[N:30]=[CH:31][C:32]([C:33]#[N:34])=[C:28]3[N:27]=2)[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 149331-(3-Chlorophenyl)ethanoneHCID 153380121-(3-Chlorophenyl)-4,4,4-trifluorobutane-1,3-dioneHCID 178510443HCID 178510443, compound

Product 1

HCID 67213123HCID 67213123, compoundYield 46.5%

Procedure

Reaction of 1-(3-chloro-phenyl)-4,4,4-trifluoro-butane-1,3-dione (251 mg, 1.0 mmol), prepared from commercially available 3-chloro-acetophenone according to general procedure A, and 3-amino-4-cyano-pyrazole (108 mg, 1.0 mmol) according to general procedure B yielded the title compound as a yellow solid (150 mg, 46%). MS (ISP) 323.1 [(M+H)+]; mp 204° C.

Sources & evidence

ORD record
ord-8a6c763d1494403e8f7af02d4b9e5a2f
Source dataset
uspto-grants-2009_04
Patent number
US07514443B2

Reaction notes

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