HCID 12588958, compound → HCID 67213153, compound

HRID 2108399Notes

Reaction equation

HRID 2108399 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:9](=O)[CH2:10][C:11](=O)[C:12]([F:15])([F:14])[F:13])[CH:5]=[CH:6][C:7]=1[F:8].[NH2:18][C:19]1[C:23]([C:24]#[N:25])=[CH:22][NH:21][N:20]=1>>[F:1][C:2]1[CH:3]=[C:4]([C:9]2[CH:10]=[C:11]([C:12]([F:15])([F:14])[F:13])[N:20]3[N:21]=[CH:22][C:23]([C:24]#[N:25])=[C:19]3[N:18]=2)[CH:5]=[CH:6][C:7]=1[F:8]

Participants

3

Reactant 2

HCID 12588958HCID 12588958, compoundHCID 178510443HCID 178510443, compound

Product 1

HCID 67213153HCID 67213153, compoundYield 42.3%

Procedure

Reaction of 1-(3,4-difluoro-phenyl)-4,4,4-trifluoro-butane-1,3-dione (252 mg, 1.0 mmol), prepared from commercially available 3,4-difluoro-acetophenone according to general procedure A, and 3-amino-4-cyano-pyrazole (108 mg, 1.0 mmol) according to general procedure B yielded the title compound as a light yellow solid (137 mg, 42%).

Sources & evidence

ORD record
ord-6b0e1da32afc41889741c8a53927870d
Source dataset
uspto-grants-2009_04
Patent number
US07514443B2

Reaction notes

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