HCID 86598655, compound → HCID 11428764, compound

HRID 2108400Notes

Reaction equation

HRID 2108400 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=O)[CH2:9][C:10](=O)[C:11]([F:14])([F:13])[F:12])=[CH:4][C:3]=1[C:17]([F:20])([F:19])[F:18].[NH2:21][C:22]1[C:26]([C:27]#[N:28])=[CH:25][NH:24][N:23]=1>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([C:11]([F:14])([F:13])[F:12])[N:23]3[N:24]=[CH:25][C:26]([C:27]#[N:28])=[C:22]3[N:21]=2)=[CH:4][C:3]=1[C:17]([F:20])([F:19])[F:18]

Participants

3

Reactant 2

HCID 86598655HCID 86598655, compoundHCID 178510443HCID 178510443, compound

Product 1

HCID 11428764HCID 11428764, compoundYield 38.5%

Procedure

Reaction of 1-(4-fluoro-3-trifluoromethyl-phenyl)-4,4,4-trifluoro-butane-1,3-dione (302 mg, 1.0 mmol), prepared from commercially available 4-fluoro3-trifluoromethyl-acetophenone according to general procedure A, and 3-amino-4-cyano-pyrazole (108 mg, 1.0 mmol) according to general procedure B yielded the title compound as an off-white solid (144 mg, 38%). MS (ISP) 375.0 [(M+H)+]; mp 204° C.

Sources & evidence

ORD record
ord-5c5e6b5309ac456e8dc34e0bc07584ee
Source dataset
uspto-grants-2009_04
Patent number
US07514443B2

Reaction notes

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