HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-amino-5-methyl-1H-pyrazole-4-carbonitrile → 2-Methyl-5-(3-trifluoromethyl-phenyl)-7-trifluoromethyl-pyrazolo[1,5-a]pyrimidine-3-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-amino-5-methyl-1H-pyrazole-4-carbonitrile | HCID 227460 | — |
| Reactant | 4,4,4-Trifluoro-1-[3-(trifluoromethyl)phenyl]butane-1,3-dione | HCID 16227957 | — |
| Product | 2-Methyl-5-(3-trifluoromethyl-phenyl)-7-trifluoromethyl-pyrazolo[1,5-a]pyrimidine-3-carbonitrile | HCID 86598659 | 73.5% |
Reaction Steps
Reaction of 1-(3-trifluoromethyl-phenyl)-4,4,4-trifluoro-butane-1,3-dione (284 mg, 1.0 mmol), prepared from commercially available 3-trifluoromethyl-acetophenone according to general procedure A, and commercially available 3-amino-4-cyano-5-methyl-pyrazole (122 mg, 1.0 mmol) according to general procedure B yielded the title compound as a light yellow solid (272 mg, 73%). MS (ISP) 371.1 [(M+H)+]; mp 215° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07514443B2 |
| Source dataset | uspto-grants-2009_04 |
| ORD ID | ord-d07f7e7f8dc04679b810ab914ff4fac7 |
| Source note | uspto-grants-2009_04 |