HCID 86598679, compound → HCID 11272593, compound

HRID 2108463Notes

Reaction equation

HRID 2108463 reaction equation
[F:1][C:2]([F:25])([F:24])[CH2:3][O:4][C:5]1[CH:6]=[C:7]([C:15](=O)[CH2:16][C:17](=O)[C:18]([F:21])([F:20])[F:19])[CH:8]=[CH:9][C:10]=1[C:11]([F:14])([F:13])[F:12].[NH2:26][C:27]1[C:31]([C:32]2[CH:37]=[C:36]([CH3:38])[N:35]=[C:34]([CH3:39])[CH:33]=2)=[CH:30][NH:29][N:28]=1>>[CH3:38][C:36]1[CH:37]=[C:32]([C:31]2[CH:30]=[N:29][N:28]3[C:17]([C:18]([F:21])([F:20])[F:19])=[CH:16][C:15]([C:7]4[CH:8]=[CH:9][C:10]([C:11]([F:14])([F:13])[F:12])=[C:5]([O:4][CH2:3][C:2]([F:25])([F:24])[F:1])[CH:6]=4)=[N:26][C:27]=23)[CH:33]=[C:34]([CH3:39])[N:35]=1

Participants

3

Reactant 2

HCID 86598679HCID 86598679, compoundHCID 178422939HCID 178422939, compound

Product 1

HCID 11272593HCID 11272593, compoundYield 52%

Procedure

Reaction of 1-[3-(2,2,2-trifluoroethoxy)-4-trifluoromethyl-phenyl]-4,4,4-trifluoro-butane-1,3-dione (191 mg, 0.5 mmol), prepared from 4-(2,2,2-trifluoroethoxy)-3-trifluoromethyl-acetophenone (synthesis: see part acetophenone derivatives) according to general procedure A, and 3-amino-4-(2,6-dimethyl-4-pyridinyl)-pyrazole [prepared from 4-cyanomethyl-2,6-dimethyl-pyridine, CAS No. 130138-46-4, as described in Bioorg. Med. Chem. Lett. 12 (2002) 3537-3541] (94 mg, 0.5 mmol) according to general procedure B yielded the title compound as a yellow solid (139 mg, 52%). MS (ISP) 535.4 [(M+H)+]; mp 245° C.

Sources & evidence

ORD record
ord-e35419e48f96445dbb8e151bf8d0f7ff
Source dataset
uspto-grants-2009_04
Patent number
US07514443B2

Reaction notes

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