HCID 86598680, compound → HCID 11752187, compound

HRID 2108466Notes

Reaction equation

HRID 2108466 reaction equation
[F:1][C:2]([F:23])([F:22])[C:3]1[CH:4]=[C:5]([C:13](=O)[CH2:14][C:15](=O)[C:16]([F:19])([F:18])[F:17])[CH:6]=[CH:7][C:8]=1[C:9]([F:12])([F:11])[F:10].[NH2:24][C:25]1[C:29]([C:30]2[CH:35]=[CH:34][N:33]=[C:32]([CH3:36])[CH:31]=2)=[CH:28][NH:27][N:26]=1>>[F:1][C:2]([F:23])([F:22])[C:3]1[CH:4]=[C:5]([C:13]2[CH:14]=[C:15]([C:16]([F:19])([F:18])[F:17])[N:26]3[N:27]=[CH:28][C:29]([C:30]4[CH:35]=[CH:34][N:33]=[C:32]([CH3:36])[CH:31]=4)=[C:25]3[N:24]=2)[CH:6]=[CH:7][C:8]=1[C:9]([F:12])([F:11])[F:10]

Participants

3

Reactant 2

HCID 86598680HCID 86598680, compoundHCID 178422940HCID 178422940, compound

Product 1

HCID 11752187HCID 11752187, compoundYield 38%

Procedure

Reaction of 1-(3,4-bis-trifluoromethyl-phenyl)-4,4,4-trifluoro-butane-1,3-dione (176 mg, 0.5 mmol), prepared from commercially available 3,4-bis-trifluoromethyl-acetophenone [CAS No. 129604-25-7] according to general procedure A, and 3-amino-4-(2-methyl-4-pyridinyl)-pyrazole [prepared from 4-cyanomethyl-2-methyl-pyridine, as described in Bioorg. Med. Chem. Lett. 12 (2002) 3537-3541] (87 mg, 0.5 mmol) according to general procedure B yielded the title compound as a yellow solid (93 mg, 38%). MS (ISP) 491.3 [(M+H)+]; mp 223° C.

Sources & evidence

ORD record
ord-1b1f4c2a6d524cf88284cdd4bc250b1e
Source dataset
uspto-grants-2009_04
Patent number
US07514443B2

Reaction notes

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