2,4-Butanedione, 1,1,1-trifluoro-4-(4-methoxyphenyl)- → HCID 67213500, compound

HRID 2108470Notes

Reaction equation

HRID 2108470 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9](=O)[CH2:10][C:11](=O)[C:12]([F:15])([F:14])[F:13])=[CH:5][CH:4]=1.[NH2:18][C:19]1[C:23]([C:24]2[CH:29]=[CH:28][N:27]=[CH:26][CH:25]=2)=[CH:22][NH:21][N:20]=1>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:10]=[C:11]([C:12]([F:15])([F:14])[F:13])[N:20]3[N:21]=[CH:22][C:23]([C:24]4[CH:29]=[CH:28][N:27]=[CH:26][CH:25]=4)=[C:19]3[N:18]=2)=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 1399032,4-Butanedione, 1,1,1-trifluoro-4-(4-methoxyphenyl)-HCID 178509259HCID 178509259, compound

Product 1

HCID 67213500HCID 67213500, compoundYield 59.4%

Procedure

Reaction of 1-(4-methoxy-phenyl)-4,4,4-trifluoro-butane-1,3-dione (123 mg, 0.5 mmol), prepared from commercially available 4-methoxy-acetophenone according to general procedure A, and 3-amino-4-(4-pyridinyl)-pyrazole [CAS No. 216661-87-9; prepared from 4-cyanomethyl-pyridine as described in Bioorg. Med. Chem. Lett. 12 (2002) 3537-3541] (80 mg, 0.5 mmol) according to general procedure B yielded the title compound as a yellow solid (110 mg, 59%). MS (ISP) 371.2 [(M+H)+]; mp 244° C.

Sources & evidence

ORD record
ord-635271a36c2448bc891473b16ecfa872
Source dataset
uspto-grants-2009_04
Patent number
US07514443B2

Reaction notes

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