HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Acetylpyridine → 2-Pyridin-4-yl-4-trifluoromethyl-imidazo[1,5-a]pyrimidine-8-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Acetylpyridine | HCID 14282 | — |
| Reactant | 5-amino-1H-imidazole-4-carbonitrile | HCID 78777 | — |
| Reactant | 4,4,4-Trifluoro-1-(pyridin-4-yl)butane-1,3-dione | HCID 238298 | — |
| Product | 2-Pyridin-4-yl-4-trifluoromethyl-imidazo[1,5-a]pyrimidine-8-carbonitrile | HCID 67212991 | 27% |
Reaction Steps
Reaction of 1-pyridin-4-yl-4,4,4-trifluoro-butane-1,3-dione (217 mg, 1.0 mmol), prepared from commercially available 4-acetylpyridine according to general procedure A, and 4-amino-5-cyano-1H-imidazole (108 mg, 1.0 mmol) according to general procedure B yielded the title compound as a yellow solid (77 mg, 27%). MS (ISP) 289.8 [(M+H)+]; mp 254° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07514443B2 |
| Source dataset | uspto-grants-2009_04 |
| ORD ID | ord-cc4a8246a57842fd9f6332a957ebac62 |
| Source note | uspto-grants-2009_04 |