HCID 2782518, compound → HCID 67213722, compound

HRID 2108493Notes

Reaction equation

HRID 2108493 reaction equation
[F:1][CH:2]([F:16])[C:3](=O)[CH2:4][C:5]([C:7]1[CH:12]=[CH:11][C:10]([O:13][CH3:14])=[CH:9][CH:8]=1)=O.[NH2:17][C:18]1[C:22]([C:23]2[CH:28]=[CH:27][N:26]=[CH:25][CH:24]=2)=[CH:21][NH:20][N:19]=1>>[F:1][CH:2]([F:16])[C:3]1[N:19]2[N:20]=[CH:21][C:22]([C:23]3[CH:28]=[CH:27][N:26]=[CH:25][CH:24]=3)=[C:18]2[N:17]=[C:5]([C:7]2[CH:12]=[CH:11][C:10]([O:13][CH3:14])=[CH:9][CH:8]=2)[CH:4]=1

Participants

3

Reactant 2

HCID 2782518HCID 2782518, compoundHCID 178509259HCID 178509259, compound

Product 1

HCID 67213722HCID 67213722, compoundYield 68.1%

Procedure

Reaction of 4,4-difluoro-1-(4-methoxy-phenyl)-butane-1,3-dione (114 mg, 0.5 mmol), prepared from commercially available 4-methoxy-acetophenone according to general procedure A, and 3-amino-4-(4-pyridinyl)-pyrazole [CAS No. 216661-87-9; prepared from 4-cyanomethyl-pyridine as described in Bioorg. Med. Chem. Lett. 12 (2002) 3537-3541] (80 mg, 0.5 mmol) according to general procedure B yielded the title compound as a yellow solid (120 mg, 68%). MS (ISP) 353.2 [(M+H)+]; mp 206° C.

Sources & evidence

ORD record
ord-a635ffa334104707ac15d8d62c469510
Source dataset
uspto-grants-2009_04
Patent number
US07514443B2

Reaction notes

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