Isopropyl iodide → HCID 68563587, compound

Participants

Reaction Steps

According to the procedure described for the synthesis of [3-(4-isobutyl-morpholin-2-yl)-1H-indol-6-yl]-(4-isopropyl-piperazin-1-yl)-methanone (example 90) the title compounds was synthesized in consecutive steps from 3-morpholin-2-yl-1H-indole-6-carboxylic acid methyl ester and 2-iodopropane (commercially available) leading to 3-(4-isopropyl-morpholin-2-yl)-1H-indole-6-carboxylic acid methyl ester (MS (m/e): 303.4 (MH+)) which was converted to the title compounds according to the procedure described for the conversion of an ester functionality to a piperazine amide functionality like in example 72, step 2. The title compound was prepared from 3-(4-isopropyl-morpholin-2-yl)-1H-indole-6-carboxylic acid methyl ester and (after ester cleavage with LiOH.H2O), 1-(2-propyl)-piperazine (commercially available). The title compound was obtained as light yellow foam. MS (m/e): 399.3 (MH+).

Provenance & Evidence