8-Bromo-1-ethyl-7-methoxy-2,3,4,5-tetrahydro-1H-benzo[d]azepine → HCID 9881885, compound

HRID 2108506Notes

Reaction equation

HRID 2108506 reaction equation
ClC1C(OC)=CC2CCNCC(C)C=2C=1.C[N:17]1[CH2:23][CH:22]([CH3:24])[C:21]2[CH:25]=[C:26]([Br:31])[C:27]([O:29][CH3:30])=[CH:28][C:20]=2[CH2:19][CH2:18]1.BrC1C(OC)=CC2CCNCC(CC)C=2C=1.ClC1C(OC)=CC2CCNCC(CC)C=2C=1.IC1C(OC)=CC2CCNCC(CC)C=2C=1.COC1C(C(F)(F)F)=CC2C(C)CNCCC=2C=1.COC1C(C(F)(F)C(F)(F)F)=CC2C(C)CNCCC=2C=1>>[Br:31][C:26]1[C:27]([O:29][CH3:30])=[CH:28][C:20]2[CH2:19][CH2:18][NH:17][CH2:23][CH:22]([CH3:24])[C:21]=2[CH:25]=1

Participants

8

Reactant 7

HCID 99940088-Bromo-1-ethyl-7-methoxy-2,3,4,5-tetrahydro-1H-benzo[d]azepineHCID 100154147-Methoxy-1-methyl-8-trifluoromethyl-2,3,4,5-tetrahydro-1H-benzo[d]azepineHCID 100366298-Chloro-7-methoxy-1-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepineHCID 100601798-Chloro-1-ethyl-7-methoxy-2,3,4,5-tetrahydro-1H-3-benzazepineHCID 10085262N-Methyl-8-bromo-7-methoxy-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepineHCID 10314616HCID 10314616, compoundHCID 104254257-Methoxy-1-methyl-8-pentafluoroethyl-2,3,4,5-tetrahydro-1H-3-benzazepine

Product 1

HCID 9881885HCID 9881885, compound

Procedure

8-Chloro-7-methoxy-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine; 8-Iodo-7-methoxy-1-methyl-2,3,4,5-taetrhydro-1H-3-benzazepine; N-Methyl-8-bromo-7-methoxy-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine; 8-Bromo-1-ethyl-7-methoxy-2,3,4,5-tetrahydro-1H-3-benzazepine; 8-Chloro-1-ethyl-7-methoxy-2,3,4,5-tetrahydro-1H-3-benzazepine; 8-Iodo-1-ethyl-7-methoxy-2,3,4,5-tetrahydro-1H-3-benzazepine; 7-Methoxy-1-methyl-8-trifluoromethyl-2,3,4,5-tetrahydro-1H-3-benzazepine; and 7-Methoxy-1-methyl-8-pentafluoroethyl-2,3,4,5-tetrahydro-1H-3-benzazepine; or a pharmaceutically acceptable salt, solvate or hydrate thereof.

Sources & evidence

ORD record
ord-f58fcae662c047fa8a4afe73058830ec
Source dataset
uspto-grants-2009_04
Patent number
US07514422B2

Reaction notes

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