2-Aminobenzophenone → HCID 57632408, compound

Participants

Reaction Steps

To a cooled (−78° C.) solution of 2,4-dichloro-5-nitropyrimidine (0.53 g, 2.75 mmol) in THF (3 mL) was added a solution of (2-aminophenyl)(phenyl)methanone (0.30 g, 1.55 mmol) and N,N-diisopropylethylamine (0.5 mL, 3.0 mmol) in THF (2.0 mL). The reaction was stirred for 2.0 hours. The reaction was then poured onto ice and allowed to warm to room temperature then was filtered, washing the solid with water. The isolated solid was dried under vacuum to give {2-[(2-chloro-5-nitropyrimidin-4-yl)amino]phenyl}(phenyl)methanone (496 mg, 90%) as a yellow solid. 1H NMR (DMSO-d6/D2O): δ 9.06 (s, 1H), 7.96 (d, 1H), 7.76-7.44 (m, 8 H). MS m/z 354 (M+1).

Provenance & Evidence