反应详情

A mixture of 5-(4-amino-phenyl)-furan-2-carboxylic acid(1-aza-bicyclo[2.2.2]oct-3-yl)-amide (0.155 g, 0.5 mmol), dichloromethane (25 ml) and benzoyl chloride (0.117 ml, 1.0 mmol) was stirred for 3 hours at room temperature. The crude mixture was filtered. The product was precipitated from the filtrate by adding diethyl ether (5 ml) as hydrochloric acid salt. Yield 56 mg (25%). M.p. 215° C.

1. filtrationThe crude mixture was filtered
2. customThe product was precipitated from the filtrate
3. additionby adding diethyl ether (5 ml) as hydrochloric acid salt