Dimethylformamide → HCID 135491729, compound

Participants

Reaction Steps

A suspension of 5-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3,4-thiadiazol-2-amine (0.050 g, 0.23 mmol), 3-methoxyphenylacetic acid (0.038 g, 0.23 mml), triethylamine (0.1 mL) and BtSO2CH3 (0.055 g, 0.28 mml) in THF (3 mL) and DMF (0.3 mL) was heated in a microwave oven for 20 min. The brown solution was added to water (50 mL) and ethyl acetate (50 mL). Brine (10 ml) was added to separate the layers. The organic phase was separated and washed with water (2×50 mL). The organic layer was concentrated to give a solid which was placed in a small Buchner funnel and washed with methanol (2×5 mL) and ethyl acetate (2×5 mL). The brown solid collected was dried under vacuum to afford the desired product (0.018 g, 21%).

Provenance & Evidence