Ammonium Hydroxide → HCID 57633117, compound

Participants

Reaction Conditions

Reaction Steps

2-(3-Nitro-phenyl)-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-thiazol-2-yl]-acetamide (200 mg, 0.5 mmol) was taken in DMF-MeOH (5 mL) and added to sat. NH4OH (5 ml) and Fe powder (3eq, 83 mg). Then the suspension was heated overnight at 100° C. The brown colored reaction mixture was passed through a celite plug and washed with ethyl acetate. Then the reaction mixture was concentrated to dryness and taken up in ethyl acetate and extracted with water. The organic layer was dried and concentrated to give the desired product as a tan solid (50 mg, 30% yield).

Provenance & Evidence