huagongshe.com
HRID2108822

反应详情

EQUATION

反应方程式

HRID 2108822 的结构方程式

REACTANTS

反应物

2
结构：O=C(O)c1cn([C@@H]2C[C@@H]2F)c2c(Cl)c(F)c(F)cc2c1=O
HCID10448547

8-Chloro-6,7-difluoro-1-[(1R,2S)-2-fluorocyclopropyl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

C13H7ClF3NO3

结构：F[C@@H]1CNC[C@@H]1CNC1CC1
HCID11147857

未命名化合物

PRODUCTS

生成物

1
结构：O=C(O)c1cn([C@@H]2C[C@@H]2F)c2c(Cl)c(N3C[C@H](CNC4CC4)[C@H](F)C3)c(F)cc2c1=O
HCID66704876

未命名化合物

收率 20.5%

PROCEDURE

实验过程

Using 8-chloro-6,7-difluoro-1-[(1R,2S)-2-fluorocyclopropyl]-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid (318 mg) and (3R,4S)-3-cyclopropylaminomethyl-4-fluoropyrrolidine (174 mg), the same procedure was followed as in Example 23 to give 8-chloro-7-[(3S,4S)-3-cyclopropylaminomethyl-4-fluoro-1-pyrrolidinyl]-6-fluoro-1-[(1R,2S)-2-fluorocyclopropyl]-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid as a yellow solid (93.6 mg).