反应详情

A mixture of tert-butyl [(3-methyl-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)methyl]carbamate (658 mg, 2.37 mmol) and 10% hydrogen chloride-MeOH was stirred for 2 hours at ambient temperature. The formed precipitate was collected and washed with DCM to give the title compound as a white solid (436 mg, 86%). 1H NMR (CDCl3): δ 3.28 (3H, s), 3.73 (2H, brs), 7.01 (1H, d, J=7.9 Hz), 7.12 (1H, d, J=7.9 Hz), 7.28 (1H, d, J=8.5 Hz), 8.03-8.67 (3H, m), 11.02 (1H, s). MS (ESI) m/z 176 (M−H)+.

1. customThe formed precipitate was collected
2. washwashed with DCM