3-Morpholino-1-propanol → 4-Chloro-7-methoxy-6-(3-(4-morpholinyl)propoxy)quinazoline

HRID 2108890Notes

Reaction equation

HRID 2108890 reaction equation
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:13][CH3:14])=[C:9]([OH:12])[CH:10]=2)[N:5]=[CH:4][N:3]=1.[N:15]1([CH2:21][CH2:22][CH2:23]O)[CH2:20][CH2:19][O:18][CH2:17][CH2:16]1>>[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:13][CH3:14])=[C:9]([O:12][CH2:23][CH2:22][CH2:21][N:15]3[CH2:20][CH2:19][O:18][CH2:17][CH2:16]3)[CH:10]=2)[N:5]=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 1995763-Morpholino-1-propanolHCID 231324754-Chloro-7-methoxyquinazolin-6-ol

Product 1

HCID 226492214-Chloro-7-methoxy-6-(3-(4-morpholinyl)propoxy)quinazoline

Procedure

The compound was synthesised according to GP 4 from 4-chloro-6-hydroxy-7-methoxy-quinazoline and 3-Morpholin-4-yl-propan-1-ol. LC/ESI-MS: m/z=338 [M+H].

Workup

  1. customThe compound was synthesised

Sources & evidence

ORD record
ord-5581cafbe31442dd87d123d74438be8f
Source dataset
uspto-grants-2009_04
Patent number
US07514460B2

Reaction notes

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