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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2108891Generated: October 31, 2026

1-(2-Hydroxyethyl)-4-methylpiperazine → 4-Chloro-6-methoxy-7-(2-(4-methylpiperazin-1-yl)ethoxy)quinazoline

https://huagongshe.com/reaction/2108891

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(2-Hydroxyethyl)-4-methylpiperazineHCID 231184—
Reactant4-Chloro-6-methoxyquinazolin-7-olHCID 135742251—
Product4-Chloro-6-methoxy-7-(2-(4-methylpiperazin-1-yl)ethoxy)quinazolineHCID 11759499—

Reaction Steps

The compound was synthesised according to GP 4 from 4-chloro-7-hydroxy-6-methoxy-quinazoline and 2-(4-Methyl-piperazin-1-yl)-ethanol. LC/ESI-MS: m/z=337 [M+H].

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07514460B2
Source datasetuspto-grants-2009_04
ORD IDord-154642c81e614c41bf5fb67cfd4297a2
Source noteuspto-grants-2009_04