2-Morpholinoethanol → 4-Chloro-6-methoxy-7-(2-morpholinoethoxy)quinazoline

HRID 2108893Notes

Reaction equation

HRID 2108893 reaction equation
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([OH:14])=[C:9]([O:12][CH3:13])[CH:10]=2)[N:5]=[CH:4][N:3]=1.[N:15]1([CH2:21][CH2:22]O)[CH2:20][CH2:19][O:18][CH2:17][CH2:16]1>>[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:14][CH2:22][CH2:21][N:15]3[CH2:20][CH2:19][O:18][CH2:17][CH2:16]3)=[C:9]([O:12][CH3:13])[CH:10]=2)[N:5]=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 611632-MorpholinoethanolHCID 1357422514-Chloro-6-methoxyquinazolin-7-ol

Product 1

HCID 108710274-Chloro-6-methoxy-7-(2-morpholinoethoxy)quinazoline

Procedure

The compound was synthesised according to GP 4 from 4-chloro-7-hydroxy-6-methoxy-quinazoline and 2-Morpholin-4-yl-ethanol. LC/ESI-MS: m/z=324 [M+H].

Workup

  1. customThe compound was synthesised

Sources & evidence

ORD record
ord-64bf75132cb248678944309826c97045
Source dataset
uspto-grants-2009_04
Patent number
US07514460B2

Reaction notes

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