3-(Dimethylamino)-1-propanol → [3-(4-Chloro-6-methoxy-quinazolin-7-yloxy)-propyl]-dimethyl-amine

HRID 2108895Notes

Reaction equation

HRID 2108895 reaction equation
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([OH:14])=[C:9]([O:12][CH3:13])[CH:10]=2)[N:5]=[CH:4][N:3]=1.[CH3:15][N:16]([CH3:21])[CH2:17][CH2:18][CH2:19]O>>[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:14][CH2:19][CH2:18][CH2:17][N:16]([CH3:21])[CH3:15])=[C:9]([O:12][CH3:13])[CH:10]=2)[N:5]=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 766463-(Dimethylamino)-1-propanolHCID 1357422514-Chloro-6-methoxyquinazolin-7-ol

Product 1

HCID 86605671[3-(4-Chloro-6-methoxy-quinazolin-7-yloxy)-propyl]-dimethyl-amine

Procedure

The compound was synthesised according to GP 4 from 4-chloro-7-hydroxy-6-methoxy-quinazoline and 3-Dimethylamino-propan-1-ol. LC/ESI-MS: m/z=296 [M+H].

Workup

  1. customThe compound was synthesised

Sources & evidence

ORD record
ord-f5da15ada48d44ce8f5872279e43857f
Source dataset
uspto-grants-2009_04
Patent number
US07514460B2

Reaction notes

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