4-Chlorobenzoyl chloride → 4-Chloro-N-[2-(6,7-dimethoxyquinazolin-4-ylamino)benzothiazol-6-yl]benzamide

HRID 2108909Notes

Reaction equation

HRID 2108909 reaction equation
[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=[O:7])=[CH:4][CH:3]=1.[CH3:11][O:12][C:13]1[CH:14]=[C:15]2[C:20](=[CH:21][C:22]=1[O:23][CH3:24])[N:19]=[CH:18][N:17]=[C:16]2[NH:25][C:26]1[S:27][C:28]2[CH:34]=[C:33]([NH2:35])[CH:32]=[CH:31][C:29]=2[N:30]=1>>[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH:35][C:33]2[CH:32]=[CH:31][C:29]3[N:30]=[C:26]([NH:25][C:16]4[C:15]5[C:20](=[CH:21][C:22]([O:23][CH3:24])=[C:13]([O:12][CH3:11])[CH:14]=5)[N:19]=[CH:18][N:17]=4)[S:27][C:28]=3[CH:34]=2)=[O:7])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 85014-Chlorobenzoyl chlorideHCID 86248039N2-(6,7-dimethoxyquinazolin-4-yl)benzothiazole-2,6-diamine

Product 1

HCID 115768154-Chloro-N-[2-(6,7-dimethoxyquinazolin-4-ylamino)benzothiazol-6-yl]benzamide

Procedure

4-Chloro-N-[2-(6,7-dimethoxyquinazolin-4-ylamino)benzothiazol-6-yl ]benzamide was prepared from p-chlorobenzoyl chloride (15 μL, 0.113 mmol) and N2-(6,7-dimethoxyquinazolin-4-yl)benzothiazole-2,6-diamine (40 mg, 0.113 mmol) according to GP 2 (yellowish solid, 41 mg, 83 μmol, 74%). LC/ESI-MS: m/z=492 [M(35Cl)+H]+; m/z=490 [M(35Cl)−H]−; Rt=3.45 min.

Sources & evidence

ORD record
ord-9e7b4a4bb6a54de3b6f307478a2faa5f
Source dataset
uspto-grants-2009_04
Patent number
US07514460B2

Reaction notes

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