反应详情

1-(4-Chloro-3-trifluoromethylphenyl)-3-[2-(9H-purin-6-ylamino)-benzothiazol-6-yl]urea was prepared from 6-chloropurine (17 mg, 0.11 mmol) and 1-(2-aminobenzothiazol-6-yl)-3-(4-chloro-3-trifluoromethylphenyl)urea (Intermediate 3, 42.5 mg, 0.11 mmol) according to GP 1. The reaction mixture was purified by pTLC (dichloromethane:methanol=9:1) to yield a yellow solid (35.4 mg, 70 μmol, 64%). LC/ESI-MS: m/z=505 [M(35Cl)+H]+; m/z=503 [M(35Cl)−H]−; Rt=3.87 min.

1. customThe reaction mixture was purified by pTLC (dichloromethane:methanol=9:1)