6-chloro-N-(cyclopropylmethyl)pyridine-3-carboxamide → HCID 21914628, compound

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N-Cyclopropylmethyl-6-[5-(thiazol-2-ylcarbamoyl)-2-methyl-phenyl]-nicotinamide was prepared from 6-chloro-N-cyclopropylmethylnicotinamide (Intermediate 1) and 4-methyl-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-N-(thiazol-2-yl)-benzamide (Intermediate 11) using General Method B. LCMS: retention time 2.99 min, MH+393. NMR: δH [2H6]-DMSO 12.71, (1H, b), 9.13, (1H, s), 8.86, (1H, t), 8.34, (1H, d), 8.21, (1H, s), 8.07, (1H, d), 7.81, (1H, d), 7.57, (1H, d), 7.52, (1H, d), 7.29, (1H, d), 3.21, (2H, t), 2.45, (3H, s), 1.07, (1H, m), 0.47, (2H, m), 0.27, (2H, m).

Provenance & Evidence