Acetic Anhydride → 1-Acetyl-6-fluoro-1,3-dihydro-2H-indol-2-one

HRID 2109014Notes

Reaction equation

HRID 2109014 reaction equation
[F:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][C:7](=[O:11])[NH:8]2)=[CH:4][CH:3]=1.[C:12](OC(=O)C)(=[O:14])[CH3:13]>>[C:12]([N:8]1[C:9]2[C:5](=[CH:4][CH:3]=[C:2]([F:1])[CH:10]=2)[CH2:6][C:7]1=[O:11])(=[O:14])[CH3:13]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 37310136-fluoro-2,3-dihydro-1H-indol-2-one

Product 1

HCID 581603571-Acetyl-6-fluoro-1,3-dihydro-2H-indol-2-one

Procedure

82.5 g 6-fluoro-2-indolinone (educt IV) are stirred in 180 ml acetic anhydride for 3 hours at 130° C. After cooling to ambient temperature the precipitate is suction filtered, washed with 100 ml of petroleum ether and dried.

Workup

  1. filtrationfiltered
  2. washwashed with 100 ml of petroleum ether
  3. customdried

Sources & evidence

ORD record
ord-35f07def8a1a43688f4d240ec387559b
Source dataset
uspto-grants-2009_04
Patent number
US07514468B2

Reaction notes

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